On October 3, Shimadzu Corporation released the Nexera CL LCMS system in Japan. The system is designed for clinical applications, such as analyzing target components in blood, urine, or other biological samples. It consists of a separation unit and a detection unit. The separation unit is a liquid chromatograph (LC) that separates target substances based on their chemical characteristics. The detection unit is either a mass spectrometer that separates and detects substances by mass or a UV detector that detects them by light absorption.
This product has been notified in Japan as a Class I medical device under the Pharmaceuticals and Medical Devices Act (PMD Act), which ensures the quality, efficacy, and safety of pharmaceuticals and medical devices.

Nexera CL LCMS System

Liquid chromatograph mass spectrometer (LC-MS) systems are used for R&D and quality control applications in a wide range of fields, such as pharmaceuticals, chemicals, foods, and environmental testing. Due to instrument advancements in recent years, the scope of clinical applications has been expanding, such as neonatal mass screening and therapeutic drug monitoring in blood. Compared to immunoassay methods, LC-MS analysis generally allows simultaneous measurement of more components, offers comparable sensitivity, and achieves higher precision by avoiding cross-reactions between different antibodies. Consequently, LC-MS systems are now used in the clinical field.

Therefore, in 2015, Shimadzu released the Nexera LC-MS/MS and Prominence LC-MS/MS systems (Class I medical devices) for clinical applications in Japan. Similarly, Shimadzu has also been releasing LC and LC-MS products in the United States and Europe. The new Nexera CL LCMS system features a state-of-the-art separation unit and an expanded line of UV detector options, some of which can be added as optional units. This system has been released to satisfy a broader range of customer needs.

Features

1. Developed with the Separation Unit from the Flagship LC Model for Industrial and Research Applications

The Nexera CL LCMS system was developed to analyze target components in biological samples, such as blood. It is based on the separation unit of the flagship LC model, which was previously released as a non-medical device for industrial and research applications. After the Nexera series LC systems for industrial/research applications were released in March 2019, they have become global long-selling models that have achieved an extensive track record analyzing a wide variety of samples in a wide variety of fields.

2. Same Easy Maintenance as Previous Models

The series offers the same easy maintainability as previous models. Users can quickly and easily replace the DL (desolvation line) and ESI capillary, which deliver LC-separated samples into the vacuum section of the mass spectrometer. These components can be replaced without stopping the mass spectrometer and while maintaining the vacuum, thereby minimizing analysis downtime.

3. Expanded Line of Optional Products

To satisfy a wide range of analytical needs, we have developed an APCI-type (atmospheric pressure chemical ionization) ionization unit (sold separately). To meet the needs of multi-sample analysis, the system can also be connected to a plate changer. The plate changer allows up to 1536 samples to be analyzed continuously.